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However, MPA pharmacokinetics have not been thoroughly studied in paediatric blood or marrow transplant recipients and guidance for optimal dosing of MPA in children is lacking [ 15 ].

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The AUC of MPA over a 12 h dose interval at steady-state is generally agreed to be the most reliable metric associated with the risk of acute rejection [ 20 , 21 ].

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Macrophagic myofasciitis and aluminium-containing vaccines

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Previous population pharmacokinetic studies involved only oral administration of MMF.

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Description: The inclusion of albumin concentration as an albumin-dependent scaling of MPA concentration, rather than as a covariate on CL, resulted in parameter values with a high degree of uncertainty.

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